LUNA, from Universal Audio, uses the AU versions of the Sessionwire plugins on a Mac. AU plugins load by default; VST3 is off unless you turn it on in LUNA's Plug-In Manager. On Windows, LUNA uses VST3.

If you use an Apollo interface, turn off ARM (Accelerated Realtime Monitoring) before you use the Sessionwire plugins. While a track is armed with ARM on, non-UAD plugins on it are bypassed.
ARM is one setting for the whole LUNA project. Turn it off with the ARM button in the Global Controls at the top of the LUNA window, or from Transport > Accelerated Realtime Monitoring. It only appears when you're using an Apollo.
On a current Apple Silicon Mac you rarely need ARM. Lower LUNA's buffer size and monitor through LUNA instead.
LUNA has no documented way to record a bus onto an audio track, so recording a Guest's HQ Audio in LUNA isn't straightforward. Have the performer record on their side and send you the files, which also gives you a better recording. See Record someone with the Receive plugin.
If people hear themselves echo in Talkback and you use an Apollo on a Mac, see Why do I hear an echo in Talkback?